Irvingia Extract for Leptin Resistance & Appetite Control
Irvingia extract is used in the production of dietary supplements that may boost weight loss by potentially reversing the body’s resistance to leptin hormone.
The Irvingia gabonensis plant is more commonly referred to as African mango and is utilized globally for weight loss and for maintenance of weight.
Irvinga has been found in clinical studies to lower the levels of bad cholesterol and boost the levels of good cholesterol.
It as well lowers triglyceride counts and boost the efficient breakdown and assimilation of fatty acids all through the body.
Irvingia gabonensis extract may assist minimize appetite and assist to control cravings for food. It is a safer than stimulant-based weight loss supplement that can frequently trigger off unnecessary side effects.
Irvingia extract, suppresses the appetite of obese and/or overweight individuals naturally and in this way makes it simpler to attain and maintain healthy weight levels. The effects of Irvingia extract is more pronounced when it is combined with a nutritious diet and regular exercise.
Irvingia Extracts, Leptin and Adipocytes
Irvingia extracts are thought to boost the sensitivity of the brain to the levels of leptin inside the body.
Leptin is a hormone that helps in appetite regulation. It does this by sending signals to the hypothalamus in the brain to control cravings for food. Irvingia acts on brain receptors to regulate hunger and maintain healthy weight.
It as well excites the sympathetic nervous system to be able to burn fat more effectively and produce energy. Leptin is formed in Adipocyte cells all through the body.
Adipocytes are special fat storage cells that are present in the connective tissues. The fat in our body is in reality white adipose tissue. Adipocytes collects free circulating fatty acids in the blood and store them away to be utilized when the body needs them.
Adipocytes make use of leptin to send signal to the brain in relation to the amount of fuel they have stored and to as well signal the brain when it is necessary to eat and stock up these fat stores.
Leptin and Appetite
When the levels of leptin are high, it signals to the brain that we are satiated. When we eat and receive the required nutrients to hold the metabolism of the body, adipocytes produce and release leptin into the bloodstream. The hypothalamus identifies the increase of leptin and makes the hunger signal to cease.
In standard situations, when an individual eats a meal, leptin is released and the feeling of hunger is reduced. Nevertheless, for this to happen, the message to the hypothalamus must be received and suitably recognized.
If the signal sent by leptin is not identified by the brain, the cravings for food remains unchanged. The individual will continue to eat without ever feeling satisfied.
A few individuals are naturally less sensitive to leptin’s effect. This accounts for why some people eat large portions of food and never feel satiated due to the fact that their hypothalamus is no longer able to show normal response to the presence of leptin and no signal of “fullness” is sent to the brain.
People like this may tend to over eat. In situations like this, Irvingia extracts can reverse the desensitization of the hypothalamus to the effect of the leptin hormone and m help the individual to return to normal eating habit.
Boosting Leptin Resistance
Irvingia Extracts functions due to the fact that they help the brain to respond more to the presence of leptin. In studies carried out with rodent, it was found that high levels of leptin help to reduce the tendencies to overeat and develop obesity.
Nevertheless, when leptin was given to obese humans, unexpected results were obtained. It was hypothesized that individuals who are obese are commonly low in leptin. With low levels of leptin, the signal of satiation is not sent to the brain and this makes them to continue to be hungry.
Conversely, research found that a number of obese individuals have very high levels of leptin. While the numbers and sizes of adipocytes in the obese individuals continue to increase, the leptin production is increased. The adipocytes release high levels of leptin when food is eaten.
Nevertheless, as a result of too much presence of leptin, the hypothalamus becomes desensitized to leptin’s effects. This results to the down regulation of the receptors for leptin. They now require additionally higher levels of leptin to be activated.
In a number of obese individuals, the body has enough leptin in circulation but the hypothalamus has become resistant to its effects. Whereas, there are not yet any known causes of leptin resistance, two different major hypotheses are used to explain this occurrence.
One hypothesis is that the leptin in the blood stream is not getting to the appropriate hunger center receptors to be able to suitably regulate the appetite.
The second hypothesis is that the hunger receptors may be abnormal or have developed some form of defect.
In any of these scenarios, the individual is left with steady hunger sensations. When these hunger sensations make the individual to overeat, it results to weight gain which could lead to obesity.
This can expose the individual to the risk factors for a number of disease conditions like type 2 diabetes mellitus, stroke, cancer, heart disease, hypertension, hypercholesterolemia, hypertriglyceridemia and a whole lot of others.
Irvingia Extract minimizes Leptin Resistance
Extracts from the Irvingia gabonensis plant have been found in many studies to boost leptin sensitivity.
It is not clear the particular mechanism of action through which this happens, nevertheless, a few studies show that it down regulates the appearance of leptin, which may help to restore normal levels of sensitivity to the receptors in the hypothalamus.
African Mango extracts as well help to prevent the process of adipogensis, which is the production of new adipocytes.
It as well helps to boost the presence of adiponectin, which is a hormone that helps in lipid metabolism and glucose regulation. Population studies show that high levels of adiponectin are connected with low bodyweight.
In research trials, intake of Irvingia gabonensis supplements results in significant weight loss, especially when taken together with Cissus quadrangularis.
The use of Irvingia seed extract at a dosage of 1.05 grams three times daily when combined with 1800 kcal daily diet led to roughly four kilogram of weight loss when taken for a period of 4 weeks. On the contrary, the control group did not record any weight loss.
A different study with a standardized extract from the African Mango plant known as IGOB131 led to 12.8 kg loss of weight when taken for 10 weeks period in comparison to just 0.7 kg recorded by the control group. The individuals were given 150 mg of this standardized extract of Irvingia gabonensis two times a day for 10 weeks.
The patients given Irvingia extract as well recorded roughly 400 less calorie intake daily when compared to the control group. This indicates that African Mango is efficient as an appetite repressor even when the individuals are not consciously trying to limit their calorie intake.
Pros of Irvingia Supplement
Research is still ongoing about a lot of potential benefits of Irvingia gabonensis extract which include the following:
- Turning around the causes of leptin resistance and re-establish healthy appetite control;
- Boosting good HDL cholesterol;
- Reducing bad LDL cholesterol and total cholesterol;
- Enhancing the metabolism of fatty acids in the bloodstream;
- Greatly reducing mortality rate of obese individuals with 2 or more inches of abdominal obesity;
- Reducing the synthesis of inflammatory proteins like interferon;
- Reducing the levels of triglyceride;
- Effectively making use of glycerol-3-phosphate dehydrogenase to break down blood lipids;
- Supporting weight loss and preventing weight gain.
Cons and side effects of Irvingia Extract
- Side effects with Irvingia is not common, however a few mild side effects have been recorded. These include mild and temporary nausea, headaches and fluid retention.
- Pregnant women, nursing mothers, diabetic patients or individuals scheduled for surgery are not recommended for Irvingia gabonensis supplement.
Discuss with your doctor before you start to use the supplement. Irvingia extract can boost weight loss. For better result, it must be used with a healthy diet and a good exercise regimen.