All You Should Know About Arginine Pyroglutamate. A Must Read!
Table of Contents
Arginine Pyroglutamate is a blend of stacked amino acids that induce the secretion of Growth Hormone. Availability of GH in systemic circulation may help increase strength, and support tendons and ligaments.
It is the combination of the amino acid arginine with a molecule of pyroglutamate.
It is under continuing research for its perspective to elicit a wide array of human health benefits.
Athletes and bodybuilders use arginine pyroglutamate for its double ability to increase intravenous blood flow and enhance production of anabolic hormones, like human growth hormone (HGH).
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By inducing the secretion of GH from the pituitary, arginine pyroglutamate stimulates muscle metabolism, thereby providing nutritional support for athletes.
Arginine pyroglutamate features
- Muscle Builder
- Hormone control
- Part of the Amino Acid group
- Boosts growth hormone
How Does It Work?
Arginine pyroglutamate is a delivery form of arginine, and the L-form of arginine is a known precursor to NO (nitric oxide) production.
Arginine is an amino acid which has several roles in the body, such as assisting in the repair of muscle cells, strengthening the immune system, and promoting the secretion of several hormones.
It is suitable for anyone who wants to gain muscle size and strength. Sprinters, bodybuilders and all athletes involved in strength and power-based sports will benefit from arginine supplementation.
The effect of arginine on growth hormone levels is of most interest to people who want to lose fat and build muscle.
Growth hormone is one of the most powerful hormones in the human body because it promotes both the growth of lean muscle tissue and the loss of fat.
However, as one age, growth hormone levels drop, which is one of the reasons you lose muscle and gain fat as you advance in age.
A finding published in the prestigious New England Journal of Medicine showed that just 6 months of growth hormone treatment increased lean muscle by almost 9%.
Because arginine stimulates the natural production of growth hormone, it is a far safer and more cost-effective alternative to growth hormone treatment.
In a controlled trial, when arginine and other amino acids were combined with weight training, a greater decrease in body fat was obtained after five weeks, unlike the result that was gotten when the same exercise was combined with a placebo.
Some of the research used large doses of arginine, but more recent tests suggest that arginine pyroglutamate (arginine bound to pyroglutamic acid) is more likely to cross the blood-brain barrier and produce greater elevations in growth hormone levels.
Arginine is also needed to increase protein synthesis, which can in turn increase muscle growth, and improves wound healing.
Arginine Pyroglutamate and Cognitive Functioning
Nitric oxide is being studied for its potential roles as a neuroprotection agent, and as a treatment for degenerative mental disorders, like Parkinson’s and Alzheimer’s.
As the vasodilation effects of nitric oxide are experienced over the entire body, enhanced blood flow to the brain is also experienced.
The brain comprises only about 2% of the body’s total mass but requires roughly 20% of the body’s oxygen and energy in order to function correctly.
However, a high-intensity physical activity can deplete energy reserves needed by the brain for efficient functioning.
Thus, when athletes use up high amounts of energy to make it through their workouts, the brains suffer from lacking nutrients and energy.
Since arginine pyroglutamate has the capability of crossing the brain-blood barrier, it is able to stimulate energetic inner-brain functions, and thus enhance cognitive functioning on many levels.
Research continues to show promising results for using arginine pyroglutamate as a general neural enhancer, as it may be able to act as a cerebral-vasodilator, targeting an increase in circulation within the brain.
Arginine pyroglutamate has been shown to treat the brain-degrading effects of long-term alcoholism and general senility, and it is also used successfully as a therapy for memory disorders.
Arginine Pyroglutamate Side Effects
There are no serious side effects of arginine pyroglutamate supplementation reported, even at high doses.
Both arginine and pyroglutamate are naturally occurring substances, and the only side effect reported to date is gastronomic upset.
Although negative side effects and interactions are rare, you should always speak with your doctor before beginning any arginine pyroglutamate supplementation programs, because, even natural substances like amino acids can cause health complications if improperly administered.
What Can It Be Combined With?
Research has shown that arginine pyroglutamate combined with lysine hydrochloride elevates growth hormone levels by several hundred percents for a period of up to eight hours.
Glutamine is also a highly effective amino acid for promoting the release of growth hormone. Research has shown that just 2 grams of L-Glutamine elevate growth hormone levels by more than 400%.
Combining arginine pyroglutamate, lysine hydrochloride and Glutamine is likely to yield the greatest results in terms of muscle growth and fat loss.