L-Carnosine Dosage Guidelines

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In talking about L-carnosine dosage, it is important to say something about L-carnosine itself first.

L-carnosine is a dipeptide formed by the combination of two amino acids: beta-alanine and histidine.

It is one of the most important building blocks that can be produced in the body and is mainly found in ‘busy’ muscles including the heart, brain, skeletal muscles, and liver.

L-carnosine is frequently used as pre-workout supplements to enhance exercise performance and capacity.

By increasing muscle carnosine levels, the onset of muscle fatigue is delayed, and physical stamina is boosted.

Supplementing with L-Carnosine is popular among sportspersons and people looking for anti-aging effects.

This supplement prevents the formation of Advanced Glycation End-products (AGEs) in the body, which has been associated with hastened aging.

Research is yet to determine the optimal L-carnosine dosage as a dietary supplement, but many prefer using beta-alanine dosages instead of L-carnosine to improve the synthesis of carnosine in muscle tissue.

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Uses of L-Carnosine supplement

Athletic performance

There are claims that L-Carnosine supplements can enhance physical performance.

This can be attributed to the fact that it promotes skeletal and heart health, both of which are important in athletic routines.


Autism is a condition that promotes stunted brain development, and it is held that the oral administration of L-Carnosine can improve the situation.

Anti-aging effects

Other than maintaining mental health, L-Carnosine also helps in physical fitness and is one of the most popular longevity supplements the market has to offer.

L-carnosine also reduces diabetes complications, though it requires a doctor to see this for safe use.

More Benefits of L-Carnosine

L-Carnosine has been shown to help in the neutralization of the accumulated lactic acids in the muscles.

Some reviews are skeptical of the effectiveness of the L-Carnosine supplement in this and will recommend supplementing with Beta-alanine instead.

However, L-Carnosine benefits include:

  • Athletic performance enhancement;
  • It also promotes loss of excess weight, another important feature for athletes.
  • There are ongoing researches aiming to link L-Carnosine with diabetes treatment and management.
  • It is perceived as a potential treatment for autism, inflammations, cardiovascular disorders, and obesity.

However, all the medical conditions mentioned above are diagnosable medical conditions that should be treated by a doctor.

L-Carnosine dosage

L-Carnosine goes through several conversion processes when ingested, and it can take some time to reach peak levels.

Different reviews offer differing L-Carnosine dosage recommendations, and there are usually, no major reports of potential side effects especially when L-Carnosine is used in healthy adults.

Serum carnosine is quickly degraded through the actions of an enzyme which dissolves the bond between beta-alanine and histidine known as carnosinase.

Carnosinase returns carnosine to its base elements before it can be utilized for its various roles.

Normally, you will find L-Carnosine capsules in the measurements of 500mg, and different brands come with specific guidelines on how to take them.

It is important to go through the guidelines provided by the manufacturer.

1000mg of L-Carnosine supplement can be used daily with significant effects. The high dosage is meant to compensate for any that may be lost during the conversion processes.

Some will recommend a much lower or higher L-Carnosine dosage depending on some factors. For instance, if you are using other nootropics such a Sulbutiamine or zinc supplements.

For example, some users have been reported to use as low as 300 mg to as high as 3 g per day, however, some will advise that if you are a beginner, try 1000mg and work your way down or up the dosage in response to results.

L-Carnosine Doses for different medical conditions

The Natural Medicines Comprehensive Database, NMCD, advice the following L-carnosine dosages:

Stomach ulcers:

150 mg doses of a carnosine-zinc complex called polapre-zinc have been used daily for treating existing stomach ulcers.

Polaprezinc seems to work by impeding the functions of Helicobacter pylori bacteria which are known to damage the linings of the stomach and intestines, causing ulcerations from exposure to digestive acids.


Long-term use of a 1% eye drop solution of N-acetyl carnosine has been used to treat cataract conditions.

Two drops have been used twice daily in the eye of cataract patients without causing any adverse reactions.

Russia has approved the use of 5% carnosine eye drops for mass medical use.


Circumstantial evidence suggests L-carnosine dosage levels between 100 and 200 mg, twice daily for general pediatric health purposes.

In children with brain trauma, central processing disorders, and epilepsy, doses between 200 and 3000 mg daily may be beneficial and should be taken before breakfast and before lunch for optimal effect.


800 mg oral L-carnosine doses were delivered daily to treatment group subjects, in one study involving 31 children with an autism spectrum disorder.

This double-blind trial went on for 8 weeks, and its conclusion showed significant improvements in treatment group subjects.

Vocabulary, communication, socialization, and general behavior skills were significantly improved. And no significant improvements occurred in placebo group subjects.

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