Side Effects & Safety Report of Irvingia Gabonensis

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Irvingia Gabonensis is a natural weight loss supplement that is commonly regarded as safe with minimal risk of side effects.

When the individual takes the dosages as recommended, it is uncommon to experience side effects with Irvingia gabonensis and a few that are normally reported are mild and transient.

Some of these temporal and short-term side effects include headaches, nausea, sleep deprivation, gastrointestinal discomfort and experience of stomach gas.

Trial studies found that it was well tolerated by participants; however, it was found that it may have possible interactions when it is taken together with a few medications and when the individual is already suffering from some health conditions.

Irvingia gabonensis is as well-referred to as African mango, Ogbono, Oolong and/or Dika. Irvingia gabonensis is an African fruit-bearing plant that grows up to 130 feet tall.

It has mango-like fruits that contain a high quantity of good fats. The seeds are made up of a good quantity of valuable protein. The seed extracts are utilized in the production of dietary supplements.

It is advertised as a weight-loss supplement and has been found to minimize cravings for food and reduce appetite, boost blood glucose levels and enhance the levels of cholesterol.

Overview of Irvingia Gabonensis

Irvingia Gabonensis side effects

Irvingia Gabonensis is clinically linked with a lot of health benefits which include minimizing LDL cholesterol, boosting HDL cholesterol, up turning insulin or leptin resistance, and reducing the levels of triglyceride.

It may indirectly result in to boost in the prevention of other avoidable diseases and health conditions, like cancer, heart disease, hypertension, diabetes mellitus, stroke, and metabolic syndrome.

It functions mainly as an appetite regulatory medication and helps to prevent the occurrence of adipogenesis which means the production of additional fat. It has also been shown to boost the function of adiponectin, which helps in the breakdown of fat in the muscle.

It has been observed to minimize the levels of glucose in the blood, which can have positive effects in a lot of instances but which can as well be a source of possible side effects of Irvingia Gabonensis.

In individuals suffering from hypoglycemia or who take drugs to control blood sugar levels, this benefit can, in reality, produce a negative effect and that may make the levels of the blood sugar to fall very low.

Irvingia Gabonensis extract can as well help in the reversal of leptin resistance, which is a common occurrence among individuals who are obese.

When your body is resistant or insensitive to leptin, it makes it difficult for your brain to know when it has enough food and when to switch off the signal for food cravings.

Taking Irvingia supplements has been illustrated to fix this and boost appetite regulation and thus assist in weight loss.

Irvingia Gabonensis for Appetite Control and Weight Loss

In a particular human study, Irvingia gabonensis was found to minimize the levels of triglyceride by 44.9 percent. This was achieved by using 1.05 grams of Irvingia extract three times daily for a period of 12 weeks.

In a different study, the levels of LDL cholesterol levels reduced by more than 45 percent with an equivalent dose administered for ten weeks. Additionally, “good” HDL cholesterol levels were found boosted by over 46 percent concurrently.

In a different study, Irvingia extracts were found to regulate the levels of blood glucose. When 150 milligrams was given three times a day for ten weeks, it was found that the levels of the blood glucose got lower by 22.5 percent.

On the other hand, the control group recorded only a 5.3 percent drop.

Again, it was as well observed that 3.15 grams of Irvingia every day resulted to a 32.36 percent reduction in blood glucose after one month of taking the supplement.

In another study, gulping 150 mg of I. gabonensis IGOB131 seed extract prior to lunch and dinner daily for 10 weeks resulted in an 87 percent boost in appetite control.

This made the participants take 389 kilocalories less and this may help to reduce the circumference of the waist. It was also observed that it resulted in a 6.3 percent reduction in the decrease in overall body fat mass.

Taking Irvingia Gabonensis Together with Cissus Quadrangularis

Researchers who investigated the effects of Irvingia gabonensis when taken together with Cissus quadrangularis found an augmented boost in weight loss. C. quadrangularis has been scientifically certified as an effective weight loss supplement for the treatment of obesity.

When Cissus was taken together with 150mg doses of Irvingia for 10 weeks period, it was observed that the weight loss in the individuals got boosted from 14.63 percent of body mass which was the resultant effect of taking only Cissus to 20.06 percent weight loss when Cissus and Irvingia are taken together.

Cissus Quadrangularis is commonly safe but may result in side effects in a few individuals. There is little evidence that shows the possible side effects of taking Irvingia gabonensis with Cissus or with other weight loss ingredients. Nevertheless, there are no straight interactions observed with other natural or herbal supplements.

Irvingia Gabonensis for Insulin and Leptin Resistance

One of the most significant operational strategies of Irvingia Gabonensis in the enhancement of weight loss is by helping to boost sensitivity to leptin and prevention of leptin resistance.

Leptin is a hormone that helps in appetite regulation. It is formed in adipocytes or fat cells that are present in the connective tissues and can act as a fat storage organ for excess fatty acids from the circulatory system.

When the concentration of fats in the blood is increased, they are stored in the adipocytes to make sure that there are accessible energy resources to cater for a time of starvation.

The adipocytes send leptin into the bloodstream. The levels of leptin are determined by the mounts of fats stored. This sends a signal to the brain when there is a sufficient store of energy.

When leptin is released, it bypasses the blood-brain barrier and gets bound with hunger regulatory receptors situated at the side of the hypothalamus.

This immediately inhibits the signals that the hypothalamus is sending to the brain to eat more calories.

The ability to receive these signals of leptin is very significant in appetite control and in the prevention of weight gain.

Leptin resistance occurs when the amount of leptin released is not enough or when there is no reaction in the cell in response to the signal sent by leptin.

When this situation occurs, it means that the receptors have become insensitive to the effects of leptin.

When this situation continues for a longer period of time, the individual excess levels of leptin hormone which is common with obese individuals makes the hypothalamus to get desensitized to leptin.

This results in hormonal imbalances those result in poor regulation of appetite.

It could make the individual to lack satiation and unable to control his or her appetite. This will result in weight gain, overweight, and obesity.

This is associated with a lot of side effects and the development of a lot of health conditions associated with obesity and overweight.


  • Irvingia Gabonensis has been found to initiate a reversal of resistance to leptin in the hypothalamus.
  • It also prevents insulin resistance
  • It improves appetite regulation
  • It reduces the levels of blood sugar and boosts weight loss
  • It helps to inhibit abnormal weight gain

Cons of Irvingia Gabonensis: Side Effects and Safety

Irvingia gabonensis side effects are not common. A few side effects that have been recorded are considered trivial and temporary.

A few of these side effects include the following:

  • Gastrointestinal upset like vomiting and flatulence, and headaches.
  • It can as well result in sleep deprivation in a number of individuals
  • It is not recommended for patients of diabetics because it can affect the levels of blood glucose
  • It is not also recommended for nursing mothers and pregnant women
  • The use of the supplement must be discontinued at least two weeks before any surgical operations.

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